The meaning of the Acronym MLB is...

MLB is

• "Mike" LineBacker (Middle LineBacker)

More Meanings For MLB:

• Macro library file (Symphony)
• Major Logic Board
• Multi-Layer Board
• "Mike" LineBacker (Middle LineBacker)
• Massive Legal Budget
• Millionaires League Baseball
• Major League Bonds
• Metaproducts Language Binary
• Major Leauge Baseball
• Mindless Lame Ballgames
• Material, Labor, Burden
• Multilayer Board
• Mini Landbridge
• MINURSO Logistic Base
• Murphys Law Baseball

MLB is also in:

• Accounting
• Electronics
• File Extensions
• General
• Law
• NASA
• NFL Teams
• Transportation
• Unfiled
• United Nations